Frontotemporal Dementia

Diagnosis & Treatment

Frontotemporal dementia (FTD) is a group of conditions caused by loss of cells mainly in the frontal and temporal lobes of the brain. The main symptoms are a progressive change in personality and behaviour or progressive deterioration in language abilities.

Frontotemporal Dementia Symptoms

The main symptoms of frontotemporal dementia (FTD) are a progressive change in personality and behaviour or progressive deterioration in language abilities. There are three forms of FTD: Behavioural variant frontotemporal dementia which affects personality and behaviour, primary progressive aphasia which affects speech at first and then behaviour, and progressive non-fluent aphasia which causes people to lose their ability to recall and speak words.

As the disease progresses, it becomes increasingly difficult for people to plan or organize activities, behave appropriately in social or work settings, interact with others, and care for themselves, resulting in increasing dependency on caregivers.

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1 Consultation
Initial consultation with a specialist physician.
2 Assessment
Appointment with a neuropsychologist in the Neuropsychiatric Laboratory for computerized, detailed assessments of cognitive deficits and other neuropsychiatric issues associated with dementia.
3 Testing
Blood tests and imaging scans, outsourced to the highest quality and convenient centres in London.
4 Follow-up
When all results are available, a 2nd consultation with the doctor, where clinical diagnosis & follow-up strategy are discussed and explained.

Frontotemporal Dementia Diagnosis

At Dementech Neurosciences’ frontotemporal dementia clinic, following an in-depth consultation with one of our dementia specialists, we can arrange for clinical tests and assessments in order to confirm a diagnosis and assess the extent to which the dementia has developed. This information can help us determine the appropriate next steps and treatment plans too.


One of the tests available at our London frontotemporal dementia clinic includes assessing in vivo tau protein aggregates using a special type of brain scan called positron emission tomography (PET), which can be used to measure chemical changes within the brain and consequently study the functions of the brain. This novel imaging tool will enable early diagnosis of FTD before extensive cell loss and symptoms become evident. Additionally, Tau PET can also serve as an indicator of treatment efficacy for interventions aimed at preventing tau aggregate formation.


We also provide genetic screening and counselling for the known genes associated to the familial forms of FTD. Some people with FTD have a family history of dementia and the condition may be inherited in some of these families. Directly inherited forms of FTD are thought to account for around 10-20% of all cases of the condition. Genes that are known to cause FTD include MAPT gene (tau), progranulin (or GRN) gene or a gene called C9ORF72.


Mutations in the tau gene can cause the tau protein to behave abnormally, forming toxic clumps that can damage brain cells. We still need to understand more about how mutations in progranulin and C9ORF72 cause the disease. The C9ORF72 gene can cause individuals to develop motor neurone disease or FTD or both conditions and may affect members of the same family differently.

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Frontotemporal Dementia Treatment

Dementia can affect people in multiple and extensive ways, and we understand that addressing all aspects of the disease is important – in order to best look after the wellbeing of the individual affected, as well as their family and caregiver(s). At Dementech Neurosciences frontotemporal dementia clinic, we offer a multidisciplinary approach to treat the whole range of symptoms of FTD. Our specialist dementia team includes an in-house speech and language therapist, occupational therapist, dietitian, psychologist and psychiatrist to manage effectively cognitive symptoms. Personalised treatment plans are always our goal, and we will be happy to answer any questions you may have to ensure everything is clear.

We also offer the opportunity to participate in clinical trials testing novel pharmacological intervention, before they become available to the public, aiming to delay the progression of the disease. Caring for a loved one with dementia can also be very stressful and challenging, and it’s very important that support and self-care extends to the caregiver as well. Our frontotemporal dementia clinic team is always happy to offer guidance and advice to carers, and we are pleased to also offer caregiver support. 

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Portrait of Dr Lucio D'Anna Neurology expert
Dr Lucio D’Anna – Consultant Neurologist in London
Lead Neurologist

Dr Lucio D’Anna is a Consultant Neurologist at the Department of Stroke & Neurosciences at Imperial College London NHS Trust. He is also Honorary Senior Lecturer at the Division of Brain Sciences, Imperial College London.

Dr Soumit Singhai He completed his higher specialist training in the North East London
Dr Soumit Singhai – Parkinson’s Specialist in London
Geriatric & general internal medicine

Dr Singhai has been a Consultant Physician/Geriatrician since 2009, initially at the Homerton University Hospital Foundation Trust in London and then from 2016 he has been at the Lister Hospital in Hertfordshire.

Dr David Choluj is a Consultant Neurologist with a further extensive experience in Stroke Medicine and Neurological Rehabilitation, based in London.
Dr David Choluj – Consultant Neurologist
Lead Neurologist for MS

Dr David Choluj is a Consultant Neurologist with a further extensive experience in Stroke Medicine and Neurological Rehabilitation, based in London.

Prof. K. Ray Chaudhuri Parkinson's specialist
Prof. K. Ray Chaudhuri – Parkinson’s Specialist in London
Parkinson's Disease Expert

Professor K. Ray Chaudhuri is a world-renowned expert in Parkinson's disease. He is Professor of Neurology/Movement Disorders & Consultant Neurologist at King’s College Hospital & King’s College London and also Principal Investigator at the Maurice Wohl Clinical Neuroscience Institute.

Professor Dag Aarsland psychiatrist
Prof. Aarsland Dag – Psychiatrist London
Geriatric Psychiatry

Dag Aarsland is Professor and Head of Department of Old Age Psychiatry at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London, and Consultant psychiatrist at the Mental Health for Older Adults, South London & Maudsley NHS Health Trust, where he leads the Parkinson Spectrum Memory Clinic.

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