Technology trial for Parkinson’s disease sufferers

A new clinical trial will assess the difference that a smartphone app could make to patients with Parkinson’s Disease by monitoring the development of their condition over time.

Forty Parkinson’s patients will participate in the 30-day trial, which is being conducted by Dementech Neurosciences clinical academic centre in collaboration with Medopad, an organisation that works with some of the world’s largest healthcare systems, research institutes and technology companies to solve problems in rare, chronic and complex disease monitoring.

The trial, which has been hailed by Dementech as a significant milestone, will allow researchers to assess the difference that high tech solutions like this could make to the management of the condition. 

If successful, the app could make a difference to the thousands of Parkinson’s Disease sufferers in the UK and further afield. It is just one of many technological advances in the diagnosis and treatment of neurological disorders.

About Parkinson’s Disease

Parkinson’s is a progressive neurological condition that causes problems in the brain which worsen as the disease progresses. One adult in every 350 in the UK – around 145,000 people – is diagnosed with the condition, which causes three main symptoms, tremors, slowness of movement and muscle symptoms.

The death of nerve cells in a particular part of the brain, called the substantial niagra, means that people with the condition don’t produce enough of the chemical Dopamine. This affects the body’s ability to control movement properly, everything from walking and talking to smiling. 

The symptoms can be subtle at first but as more cells are lost, they worsen, resulting in the characteristic shaking and muscle stiffness associated with Parkinson’s in its more advanced stages. 

There may be other symptoms, too, including restless legs, dizziness, fatigue and bowel problems. As the condition progresses, people can experience increasing disability and poor health, leaving them vulnerable to infection and significantly impacting their quality of life.

Latest research into Parkinson’s Disease: Why this trial is so important

Researchers don’t understand why some people get Parkinson’s, which is an irreversible condition with no current cure. The disease affects everyone differently. Symptoms may differ from person to person and the rate at which they progress is also highly individualised. This is why the smart app trial is so important as it could help provide insights into the evolution of Parkinson’s Disease in individuals.

Dementech is a private health clinic dedicated to understanding the nature and treatment of a wide range of neurological and psychological problems, including movement disorders like Parkinson’s Disease, dementia and other neurological problems, as well as mental health issues. 

An internationally renowned team of specialist consultants is engaged in the latest research into Parkinson’s Disease. 

The team at Dementech are delighted to be collaborating with an organisation of the calibre of Medopad and will publish the results of the trial in relevant academic journals as well as on the website.

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patient with Creutzfeldt-Jakob disease

CJD or ‘Mad Cow Disease’?

Both Creutzfeldt-Jakob Disease (CJD) and its close relative Variant Creutzfeldt-Jakob Disease (vCJD) are caused by Prions, incorrectly folded proteins, which destroy brain tissue. Neither are infectious but types of CJD can be spread by exposure to infected blood products, meat or medical instruments.

BSE (Bovine Spongiform Encephalopathy) or ‘Mad Cow Disease’ is a form of Transmissible Spongiform Encephalopathy (TSEs). The ‘spongiform’ in the name refers to the fact that the infected brain is filled with holes, resembling a sponge.

CJD is a degenerative brain disorder, estimated to affect one in a million people annually worldwide. Appearing in later life usually, the onset is rapid and fatal. Early symptoms include problems with vision, coordination problems, changes in behaviour, and memory problems, which lead to blindness, involuntary movements and coma.

vCJD was acquired by humans by exposure to meat infected with BSE. It is estimated that only 1% of CJD is ‘variant’. It was discovered in 1996 in the UK and, according to the government, 260 cases have been reported since then.

 

The Different Types of CJD

When it comes Creutzfeldt-Jakob Disease, there are 4 types:

  1. Sporadic CJD
  • Sufferers have no known risk factors.
  • Most common type of CJD
  • 85% of all CJD cases

 

  1. Hereditary CJD
  • Family history of the disease
  • 10 to 15% of CJD cases

 

  1. Acquired or Iatrogenic CJD
  • Transmitted by exposure to bodily tissue during medical procedures
  • Improperly sterilised medical instruments are also thought to spread this
  • Before 1985, was spread by a treatment using glands from deceased humans

 

  1. Variant CJD (vCJD)
  • Caused by consuming meat from a cow infected with BSE AKA ‘Mad Cow Disease’
  • 1% of all CJD cases
  • Possible 10 year+ incubation period
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Image of a bran with What is Young Onset Dementia

What is Young Onset Dementia?

A lot of young and middle-aged people joke when they forget something or miss an object that is right in front of them or say the wrong word, that they have dementia. Even though it is relatively rare, Young Onset Dementia is a serious concern.

Affecting people under 65 years of age, Young Onset Dementia, also known as early onset or working-age dementia, is so-called because of the old belief that dementia was an affliction that only affected the elderly.

Dementias that affect the young are seemingly rare but this may be because younger people cannot understand or are unwilling to believe that the malady affecting them is actually Dementia. They are much less likely to visit a doctor when they are presenting symptoms of dementia and, as sad as it is, doctors may be missing the signs too.

 

Who is likely to suffer from Young Onset Dementia?

Young Onset Dementia sufferers are more likely to have inherited a genetic form, for example, frontotemporal dementia presents in 40% with a family history of the disease.

Other groups at higher risk are people from BAME backgrounds, who are less likely to receive a timely diagnosis, and people with learning disabilities are also at greater risk of developing Young Onset.

Alzheimer’s disease accounts for about 1/3 of all Young Onset sufferers and vascular dementia affects 20% of Young Onset sufferers. 10% of Young Onset sufferers have Lewy Body dementia. 20% have something rarer, like Parkinson’s or Creutzfeldt Jakob.

Early Onset Dementia affects around 42,325 people in the UK, which is 5% of all dementia sufferers in the UK. The actual number may be as high as 6-9%. That is a pretty shocking statistic and a surprise for most people reading this. It is important that people, no matter their age, receive the correct diagnosis and are given the most up-to-date treatment.

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Close up of a dementia doctor

Dementia or another condition?

Some symptoms that the majority of people would ascribe to Dementia can be brought on by other conditions, so it is vitally important that this is taken into consideration during diagnosis. Here is our guide to help you tell the conditions apart.

Urinary Tract Infection

A Urinary Tract Infection can cause a sudden bout of confusion in an older person. Rapid changes in behaviour like agitation, inability to communicate properly and withdrawal are symptoms. If the person has complained of pelvic pain, a fever, a burning during urination or they use a catheter, UTI may be the culprit. The reason for the confusion symptom is due to the UTI overwhelming the kidneys and entering the bloodstream, causing blood poisoning which affects the brain. This is a serious condition and can be life-threatening.

Subdural Hematoma

The dura is the thin membrane that covers the brain. Blood trapped in between the membrane and the brain, caused by injury and bruising, can be mistaken for Alzheimer’s. The symptoms can emerge slowly, adding to the confusion and inhibiting a correct diagnosis. If the person has had a fall prior to the onset of symptoms, it may be a Subdural Hematoma.

Depression

Signs of depression can have the appearance of Dementia. The area of overlap is large including a lack of interest in subjects the person is usually passionate about, disrupted concentrating, forgetfulness, withdrawal and excessive sleeping. The main differences between the two are that those suffering from depression display less severe symptoms, ones that come and go, and do not reference suicide as much as Dementia sufferers. Obviously, that is not a lot to go on, so diagnosis is the only real way to differentiate.

Delirium

Although the symptoms of Delirium and Dementia are similar, the difference is that Dementia and other associated neurological conditions emerge over an extended period of time and Delirium starts suddenly. Things to look out for are an unusual amount of confusion, feelings of paranoia, hallucinations, rambling, behavioural changes, distraction, disorientation and excessive alertness problems – either drowsiness or agitation. Triggers can be clashes in medication or an underlying, untreated infection. Of course, people suffering from Dementia can also display these symptoms.

Side Effects

Medicines can create a variety of side effects which can be confused with dementia. The list includes, but is not limited to, sedatives, antidepressants, anti-anxiety medication, anticonvulsants, corticosteroids and antihistamines.

Vitamin Deficiency

A lack of Vitamin B1, Vitamin B6, Folic Acid and Niacin have been linked to dementia-esque symptoms. Alcoholics can succumb to Wernicke-Korsakoff syndrome due to a long-term lack of vitamin B1. Deficiency of B12 can lead to pernicious anaemia which is also mistaken for Dementia, and as the liver stores B12 (as well as vitamins A, D and Iron), liver damage can precipitate dementia-like effects.

Hypothyroidism

Too much (hyperthyroidism) or too little (hypothyroidism) thyroid activity can mimic some of the symptoms of dementia.

Hypothyroidism happens when the gland can’t produce enough hormones. This may be due to many factors such as an autoimmune disease. Individuals experiencing hypothyroidism experience declining mental sharpness, depression, ‘foggy brain’, difficulty concentrating, mood swings, visual-spatial skills and memory loss amongst others. Other symptoms that could be clues as to whether you have hypothyroidism are difficulty losing weight/water retention, brittle fingernails, hair loss, sensitivity to cold, enlarged tongue and enlarged thyroid gland.

The most likely cause of hyperthyroidism is also autoimmune related. This causes the gland to secrete too much hormone. The symptoms which cause it to be confused with more serious neurological conditions are tremors, nervousness, agitation, anxiety, poor concentration, lack of spatial awareness, eye problems and slowed reactions.

These conditions can be reversed a lot of the time, so if you or someone you know is displaying these symptoms, seek a diagnosis.

Normal Pressure Hydrocephalus (NPH)

NPH is a brain disorder, affecting those in their 60s and 70s primarily, where excess cerebrospinal fluid enters the brain ventricles and destroys brain tissue, causing dysfunction which leads to dementia-like symptoms like reasoning problems and walking problems. It can be treated with surgery which improves the mobility aspects but has little positive effects on the sufferers reasoning.

Brain Tumour

Malignant or benign tumours can disrupt the flow of information around the brain in a similar fashion to that of dementia. Two of the most common are changes in personality and disruption of cognitive function. These can depend on the position of the tumour within the brain and there can be mimicry of many different symptoms of dementia. Symptoms of a brain tumour are increased pressure in the brain, seizures, headaches, vomiting, changes in senses. Brain tumours can be deadly and if you suspect you have one, seek treatment immediately.

Stroke

Strokes happen when the blood flow to the brain is interrupted. Cognitive abilities are suddenly disrupted. This may be the key to recognising the difference between Dementia and the stroke version known as Vascular Dementia. The similar symptoms between the two are memory loss, confusion, hallucinations and impaired motor skills. Strokes can be treated by lowering blood pressure or cholesterol with medication.

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doctor that knows what is the difference between Alzheimer's and Dementia?

What is the difference between Alzheimer’s and Dementia?

If you are unsure, do not worry. Some health professionals do not know the difference either, so you are not alone.

Dementia is an umbrella term for serious brain conditions that affect reasoning, focus, memory, communication and visual perception. Some types of serious brain conditions are named Dementia such as Vascular Dementia, Lewy Body Dementia and Frontotemporal Dementia. Alzheimer’s is a type of Dementia too.

Alzheimer’s is a degenerative brain disease that leads from difficulty remembering and apathy to difficulty speaking and walking.

To make things even more confusing for people finding out about Dementia, it is possible to have two types of Dementia at the same time. Getting the correct diagnosis is so important to aide the correct treatment.

Just remember: Alzheimer’s is a form of Dementia but Dementia is not a form of Alzheimer’s.

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Parkinson’s Patient Case Study – Dementech Neurosciences

The video is displaying the difference in life quality that can be achieved by correct diagnosis and appropriate medical treatments. The case study is based on a Parkinson’s patient that has been wheelchair-bound for over two years.

The patient achieved a very significant improvement after having a consultation with an expert neurologist in our team. That led to a change of diagnosis and change in medication. She can be seen later in the video now able to stand up and walk.

This case is one of the many that we come across. The great difficulties in managing the condition are usually due to the wrong initial diagnosis or incorrect course of treatment.

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Dementia Awareness poster for a website 2017

Dementia Awareness 2017

We recently partnered with Mediaplanet UK on the 2017 Dementia Awareness Campaign in The Guardian newspaper and online at http://bit.ly/2mjXKCT #DementiaAwareness #Dementech #Dementia

Read motivating insight from key thought leaders and learn more about how you can get involved in dementia and help inspire more community action

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Dementech Neurosciences Clinic is live

The Dementech Neurosciences Team welcomes you to a boutique clinical practice in the heart of London’s Medical District. We have put together a team of world-class healthcare experts including neurologists, psychiatrists, geriatricians, psychologists, psychotherapists, neuropsychologists, occupational therapists, dieticians, and speech and language therapists.

The website is live now, the clinic will open in September.

Please contact us for any inquiries regarding our services, we would be happy to help you.

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Nine lifestyle changes can reduce dementia risk, study says

One in three cases of dementia could be prevented if more people looked after their brain health throughout life, according to an international study published in the Lancet.

http://www.bbc.co.uk/news/health-40655566

At Dementech, using the latest imaging technologies, we are offering innovative risk-assessment appointments, including Dementech Biomarker Tool and genetic counselling. Early identification of people at risk of developing dementia is crucial. Implementing tailored  prevention strategies targeting all modifiable risk factors and making positive lifestyle changes allows us to strengthen the brain’s networks so it can continue to function in later life despite damage.

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