Advanced Parkinson's Disease Specialists in London

Advanced PD & Clinical Uncertain Parkinson’s patients can pose a diagnostic challenge, but our experts have years of experience across all facets of this complex disease. At Dementech, we’re confident in being among the best-placed specialists to help you achieve an accurate diagnosis and receive appropriate support throughout your treatment.

As PD advances to become APD, naturally, the symptoms will become more complex, although they will still vary depending on the individual. For example, patients may develop levodopa-induced postsynaptic dysregulation of striatal dopamine receptors. This would therefore require a slightly different and more complex approach to treatment, which we can facilitate.

Continuous dopaminergic stimulation is a novel therapeutic strategy for the management of Parkinson’s disease, which proposes dopaminergic agents that provide continuous stimulation of striatal dopamine receptors that will delay or prevent the onset of levodopa-related motor complications. However, pulsatile stimulation of dopamine receptors can also occur at this stage of APD. This pulsatile stimulation then leads to molecular and physiologic changes in basal ganglia neurons and the development of motor complications. These effects are reduced or avoided when dopaminergic therapies are delivered in a more continuous and physiological manner.

Most innovative, neoteric treatment strategies that provide continuous dopaminergic stimulation can be achieved with triple ‘P’ treatment in the form of a transdermal patch, pump, and continuous infusion therapies to help combat this debilitating and denervating illness.

At Dementech Neurosciences, we are delighted to be able to offer these advanced and novel treatment strategies to patients with Advanced Parkinson’s, under the supervision of our esteemed neurologist Professor Ray Chaudhuri. We follow stringent NICE guidelines and offer bespoke service and one-stop treatment.