Frontotemporal Dementia

Diagnosis & Treatment

Shortcuts
Frontotemporal dementia (FTD) is a group of conditions caused by loss of cells mainly in the frontal and temporal lobes of the brain. The main symptoms are a progressive change in personality and behaviour or progressive deterioration in language abilities.

Symptoms

The main symptoms are a progressive change in personality and behaviour or progressive deterioration in language abilities. There are three forms of FTD: behavioral variant frontotemporal dementia which affects personality and behaviour, primary progressive aphasia which affects speech at first and then behaviour and progressive nonfluent aphasia which causes people to lose their ability to recall and speak words.

 

As the disease progresses, it becomes increasingly difficult for people to plan or organize activities, behave appropriately in social or work settings, interact with others, and care for oneself, resulting in increasing dependency on caregivers.

See more
See less
1 Consultation
Initial consultation with a specialist physician.
2 Assessment
Appointment with a neuropsychologist in the Neuropsychiatric Laboratory for computerized, detailed assessments of cognitive deficits and other neuropsychiatric issues associated with dementia.
3 Testing
Blood tests and imaging scans, outsourced to the highest quality and convenient centres in London.
4 Follow-up
When all results are available, a 2nd consultation with the doctor, where clinical diagnosis & follow-up strategy are discussed and explained.

Diagnosis

At Dementech Neurosciences, we have the possibility to assess in vivo tau protein aggregates using a special type of brain scan called positron emission tomography (PET), which can be used to measure chemical changes within the brain and consequently study the functions of the brain. This novel imaging tool will enable early diagnosis of FTD before extensive cell loss and symptoms become evident. Additionally, Tau PET can also serve as an indicator of treatment efficacy for interventions aimed at preventing tau aggregate formation.

 

We also provide genetic screening and counselling for the known genes associated to the familial forms of FTD. Some people with FTD have a family history of dementia and the condition may be inherited in some of these families. Directly inherited forms of FTD are thought to account for around 10-20% of all cases of the condition. Genes that are known to cause FTD include MAPT gene (tau), progranulin (or GRN) gene or a gene called C9ORF72.

 

Mutations in the tau gene can cause the tau protein to behave abnormally, forming toxic clumps that can damage brain cells. We still need to understand more about how mutations in progranulin and C9ORF72 cause the disease. The C9ORF72 gene can cause individuals to develop motor neurone disease or FTD or both conditions and may affect members of the same family differently.

See more
See less

Treatment

At Dementech Neurosciences, we offer a multidisciplinary approach to treat all the variety of symptoms of FTD. We have in-house speech and language therapist, occupational therapist, dietitian, psychologist and psychiatrist to manage effectively cognitive symptoms.

 

Moreover, we offer the opportunity to participate in clinical trials testing novel pharmacological intervention, before they become available to the public, aiming to delay the progression of the disease. Caregivers may experience significant stresses and have a high level of burden; therefore we also offer caregiver support.

See more
See less

020 8015 0026

Book an Appointment

Loading...
Dr Lucio D’Anna
Consultant Neurologist

Dr Lucio D’Anna obtained his MD with Honours at the Medical School of the University of Udine, Italy and then he completed his Neurology training with Honours.

Dr David Choluj
Lead Neurologist for MS

Dr David Choluj is a Consultant Neurologist with a further extensive experience in Stroke Medicine and Neurological Rehabilitation, based in London.

Prof. K. Ray Chaudhuri
Parkinson's Disease Expert

Professor K. Ray Chaudhuri is a world-renowned expert in Parkinson's disease. He is Professor of Neurology/Movement Disorders & Consultant Neurologist at King’s College Hospital & King’s College London and also Principal Investigator at the Maurice Wohl Clinical Neuroscience Institute.

Prof. Aarsland Dag
Geriatric Psychiatry

Dag Aarsland is Professor and Head of Department of Old Age Psychiatry at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London, and Consultant psychiatrist at the Mental Health for Older Adults, South London & Maudsley NHS Health Trust, where he leads the Parkinson Spectrum Memory Clinic.

Dr. Vinod Metta
Lead Interventional Neurologist

Dr Vinod Metta, consultant interventional neurologist & movement disorder specialist trained at Kings College Hospital London.